Monday, October 9, 2017

Things I want to write about eventually: Exercise induced rhabdomyolysis

Exertional Rhabdomyolysis during a 246-km Continuous Running Race

SKENDERI, K. P., S. A. KAVOURAS, C. A. ANASTASIOU, N. YIANNAKOURIS and A. MATALAS. Exertional Rhabdomyolysis during a 246-km Continuous Running Race. Med. Sci. Sports Exerc., Vol. 38, No. 6, pp. 1054 – 1057, 2006. Background: To evaluate the effect of continuous, moderate-intensity ultraendurance running exercise on skeletal muscle and hepatic damage, as indicated by serum enzyme activity measured immediately following the race. Methods: Thirty-nine runners of the Spartathlon race (a 246-km continuous race from Athens to Sparta, Greece) who managed to complete the race within the 36-h limit participated in this study. Mean finishing time of the study participants was 33.3 T 0.5 h and their average age, height, and body mass were 41 T 1 yr, 174 T 1 cm, and 67.5 T 1.1 kg, respectively. Blood samples, taken a day before and immediately after completion of the race, were assayed for the following variables: creatine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyltransferase (F-GT). Results: A dramatic increase in most of muscle and liver damage indicators was observed. The mean values for CK, LDH, AST, and ALT after the race were 43,763 T 6,764, 2,300 T 285, 1,182 T 165, and 264 T 37 IUILj1, respectively. These values were 29,384 T 4,327, 585 T 89, 5,615 T 902, and 1,606 T 331% higher than the corresponding values before the race (P G 0.001) for CK, LDH, AST, and ALT, respectively. However, there was not a significant increase in F-GT levels. Conclusion: Muscle and liver damage indicators were elevated at the highest level ever reported as a result of prolonged exercise, although no severe symptoms that required hospitalization were observed in any of the participants. The data suggest that even moderate-intensity exercise of prolonged duration can induce asymptomatic exertional rhabdomyolysis. Key Words: CREATINE KINASE, LACTATE DEHYDROGENASE, SPARTATHLON, ULTRAENDURANCE EXERCISE

So tasty.



Link




Thursday, October 5, 2017

Get the NephRUN T-shirt While Fighting Multiple Myeloma

This tweet has taken off.



A few people have expressed an interest in getting one for themselves. Okay, I'm a reasonable guy. How about this deal.

If you are going to Kidney Week and you donate $50 to the Multiple Myeloma Research Foundation for my trip to Everest I will get you a t-shirt. Your donation is even tax-deductible. This needs to happen in the next 10 days for me to get the shirts in time.

If you are not going to Kidney Week, donate $100 and I will send you a shirt.

Want a shirt and you already donated to the MMRF? Shoot me a tweet (DM or @) or e-mail and we'll work this out.

After you have donated, fill out this form so I get you the right shirt and know how to get it delivered.

The shirt is really nice. The women's version is a Hanes Ladies Cool Dri V-Neck Performance Shirt and the mens is the same shirt, but crew neck.

Thursday, September 28, 2017

Have a nephrology question? #AskRenal to the rescue.

A couple of days ago, this came across my notifications



The answer came quick.




The video is here (complete with misspellings) and the Keynote file is here (with misspellings corrected)


How metabolic alkalosis causes hypokalemia from joel topf on Vimeo.
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