Recently, he told me about one of his 24-hour urine collections that he has to do as part of the study. He made 7.7 liters of urine in twenty-four hours. As I was pulling my chin off the floor, he asked me if I thought he was on placebo. No, probably not. He agreed.
He has been on "study-drug" for over a year and the polyuria is really disruptive. He is getting up 3-4 times a night and now he needs to take naps during the day because he isn't getting enough sleep at night.
His mother reached ESRD at age 55, he seems to be doing a bit better than her, possibly due to the ARB, or just due to phenotypic variance, but we used 55 as the target, that gave him roughly a dozen years or tolvaptan. Using the change in GFR from the sensitivity analysis for males you get the following:
He felt that for him the over-under was about 5 years, and since this beat that handily he was satisfied.
The patient saw a draft of this post and consented to the release of this personal health information.